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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GYS2
All Species:
16.67
Human Site:
S627
Identified Species:
28.21
UniProt:
P54840
Number Species:
13
Phosphosite Substitution
Charge Score:
0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54840
NP_068776.2
703
80989
S627
K
F
H
V
E
L
T
S
P
P
T
T
E
G
F
Chimpanzee
Pan troglodytes
XP_520790
703
80912
S627
K
F
H
V
E
L
T
S
P
P
T
T
E
G
F
Rhesus Macaque
Macaca mulatta
Q8MJ26
737
83768
E627
H
F
T
Y
E
P
S
E
A
D
A
A
Q
G
Y
Dog
Lupus familis
XP_534869
703
80957
S627
E
F
H
M
E
A
P
S
P
P
T
T
E
G
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8VCB3
704
80866
S627
K
F
H
L
E
P
T
S
P
P
M
T
D
G
F
Rat
Rattus norvegicus
P17625
704
80715
S627
K
F
H
L
E
P
T
S
P
P
T
T
D
G
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505471
733
83148
D627
Y
F
T
Y
E
P
H
D
A
D
A
A
R
G
L
Chicken
Gallus gallus
XP_416432
704
81032
A628
K
F
E
M
E
P
C
A
P
P
K
T
E
G
F
Frog
Xenopus laevis
NP_001084863
702
80811
P626
P
D
K
F
Q
M
E
P
S
A
P
P
K
T
E
Zebra Danio
Brachydanio rerio
NP_957474
700
80455
P625
P
D
T
Y
I
Y
E
P
Q
E
P
S
S
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFC8
709
81735
I634
L
D
W
R
T
L
G
I
Y
Y
R
Q
A
R
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U2D9
672
76441
M592
V
Q
E
L
A
Q
V
M
Y
D
F
C
G
Q
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23337
708
80492
V626
P
E
Q
F
K
Q
L
V
G
E
T
I
S
D
A
Red Bread Mold
Neurospora crassa
O93869
706
80888
E617
S
F
N
G
E
E
E
E
D
F
I
P
G
V
E
Conservation
Percent
Protein Identity:
100
99.7
68.1
95.7
N.A.
94
93.3
N.A.
68
84.2
80.6
71.4
N.A.
56.9
N.A.
50.9
N.A.
Protein Similarity:
100
100
81.8
98.5
N.A.
96.5
96.3
N.A.
81.5
92.1
91.4
85.9
N.A.
73.9
N.A.
67.1
N.A.
P-Site Identity:
100
100
20
73.3
N.A.
73.3
80
N.A.
20
60
0
0
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
100
40
86.6
N.A.
86.6
93.3
N.A.
20
73.3
20
6.6
N.A.
6.6
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
49
50.5
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
66.8
67.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
0
8
15
8
15
15
8
8
15
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% C
% Asp:
0
22
0
0
0
0
0
8
8
22
0
0
15
8
0
% D
% Glu:
8
8
15
0
65
8
22
15
0
15
0
0
29
0
15
% E
% Phe:
0
65
0
15
0
0
0
0
0
8
8
0
0
0
43
% F
% Gly:
0
0
0
8
0
0
8
0
8
0
0
0
15
58
0
% G
% His:
8
0
36
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
8
0
0
8
8
0
0
0
% I
% Lys:
36
0
8
0
8
0
0
0
0
0
8
0
8
0
0
% K
% Leu:
8
0
0
22
0
22
8
0
0
0
0
0
0
0
8
% L
% Met:
0
0
0
15
0
8
0
8
0
0
8
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
22
0
0
0
0
36
8
15
43
43
15
15
0
0
0
% P
% Gln:
0
8
8
0
8
15
0
0
8
0
0
8
8
8
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
8
0
8
8
0
% R
% Ser:
8
0
0
0
0
0
8
36
8
0
0
8
15
0
8
% S
% Thr:
0
0
22
0
8
0
29
0
0
0
36
43
0
8
0
% T
% Val:
8
0
0
15
0
0
8
8
0
0
0
0
0
8
8
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
22
0
8
0
0
15
8
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _